Zinc deficiency and IL-6 -174G/C polymorphism in old people from different European countries: effect of zinc supplementation. ZINCAGE study.

doi:10.1016/j.exger.2008.01.001

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Zinc deficiency and IL-6 -174G/C polymorphism in old people from different European countries: effect of zinc supplementation. ZINCAGE study.

Experimental gerontology - 1 May 2008

Mocchegiani Eugenio, Giacconi Robertina, Costarelli Laura, Muti Elisa, Cipriano Catia, Tesei Silvia, Pierpaoli Sara, Giuli Cinzia, Papa Roberta, Marcellini Fiorella, Gasparini Nazzarena, Pierandrei Romeo, Piacenza Francesco, Mariani Ermina, Monti Daniela, Dedoussis George, Kanoni Stavroula, Herbein Georges, Fulop Tamas, Rink Lothar, Jajte Jolanta, Malavolta Marco

Abstract excerpt

IL-6 SNP at position -174 is associated with age-related diseases characterized by an impaired Zn status. This polymorphism seems also relevant in regulating the expression of proteins, such as Metallothioneins (MT), involved in the modulation of Zn homeostasis. Since high IL-6 levels in elderly induce hypozinchemia, the IL-6-174 SNP may be useful to identify old subjects who are at risk for Zn deficiency. The...

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PMID: 18267353
DOI: 10.1016/j.exger.2008.01.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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