Article
Effect of ZIP2 Gln/Arg/Leu (rs2234632) polymorphism on zinc homeostasis and inflammatory response following zinc supplementation.
BioFactors (Oxford, England) - 1 Jan 2000
Giacconi Robertina, Costarelli Laura, Malavolta Marco, Cardelli Maurizio, Galeazzi Roberta, Piacenza Francesco, Gasparini Nazzarena, Basso Andrea, Mariani Erminia, Fulop Tamas, Rink Lothar, Dedoussis George, Herbein Georges, Jajte Jolanta, Provinciali Mauro, Busco Franco, Mocchegiani Eugenio
Abstract excerpt
Zinc dyshomeostasis may lead to an augmented production of proinflammatory cytokines promoting chronic inflammation and increasing the susceptibility to age-related diseases. Several studies suggest that the zinc transporter protein ZIP2 may play a relevant role in the immune system especially during zinc deficiency, while a polymorphism on the coding region of ZIP2 gene (Gln/Arg/Leu) has been associated with...
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