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Article

Polymorphisms in MT1a gene coding region are associated with longevity in Italian Central female population.

Biogerontology - 1 Jan 2000

Cipriano Catia, Malavolta Marco, Costarelli Laura, Giacconi Robertina, Muti Elisa, Gasparini Nazzarena, Cardelli Maurizio, Monti Daniela, Mariani Erminia, Mocchegiani Eugenio

Abstract excerpt

Metallothioneins (MTs) play a pivotal role in zinc-related cell homeostasis because of their high affinity for zinc, which is in turn fundamental for immune response and antioxidant activity. MTs regulate zinc homeostasis by binding zinc and releasing zinc at the occurrence for immune response. The zinc release by MT is very limited in chronic inflammation and ageing. Some polymorphisms of MTs gene, in particular...

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PMID: 16955215
DOI: 10.1007/s10522-006-9050-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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