Article
Effects of interleukin-6 -174C/G and metallothionein 1A +647A/C single-nucleotide polymorphisms on zinc-regulated gene expression in ageing.
Experimental gerontology - 1 May 2008
Mazzatti D J, Malavolta M, White A J, Costarelli L, Giacconi R, Muti E, Cipriano C, Powell J R, Mocchegiani E
Abstract excerpt
Decreased zinc ion availability in ageing is associated with altered immune response. One of the main regulators of zinc availability is metallothionein. Metallothionein induction is under the control of interleukin-6, a pro-inflammatory cytokine whose production is associated with poor ageing. The production of interleukin-6 is controlled, in part, by variability in the -174 nucleotide position. Under conditions...
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