Cross-lineage rearrangement of antigen receptor genes in atypical chronic myeloid leukemia.
Leukemia - 1 Mar 1991
Mangi M H, Layton D M, Tobal K, Mufti G J
Abstract excerpt
The configuration of immunoglobulin (Ig) and T-cell receptor (TCR) genes was investigated in a case of atypical chronic myeloid leukemia (aCML) lacking a cytogenetically detectable Philadelphia chromosome and molecular evidence of breakpoint cluster region (bcr) rearrangement as determined by 5' and 3' bcr gene probes. Dual clonal rearrangement of Ig-heavy (H) and TCR-delta chain genes was identified. The genes...
Topics
Aged
Alleles
Bacterial Proteins
DNA Probes
DNA, Neoplasm
Deoxyribonuclease BamHI
Deoxyribonucleases, Type II Site-Specific
Gene Rearrangement
Humans
Immunoglobulin Heavy Chains
Immunoglobulins
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Male
Receptors, Antigen
Receptors, Antigen, T-Cell
Receptors, Antigen, T-Cell, gamma-delta
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Cross-lineage rearrangement of antigen receptor genes in atypical chronic myeloid leukemia.PMID 1826535Read ↗
