Article
N-acetyltransferase 2 and bladder cancer: an overview and consideration of the evidence for gene-environment interaction.
British journal of cancer - 1 Aug 2000
Green J, Banks E, Berrington A, Darby S, Deo H, Newton R
Abstract excerpt
Genetic polymorphism of the carcinogen metabolizing enzyme N-acetyl transferase 2 (NAT2) may influence susceptibility to bladder cancers related to smoking or to occupational exposure to arylamine carcinogens. This article reviews the results of 21 published case-control studies of NAT2 polymorphism and bladder-cancer risk, with a total of 2700 cases and 3426 controls. The published evidence suggests that NAT2...
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