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Article

Glis3 Regulates Neurogenin 3 Expression in Pancreatic β-Cells and Interacts with Its Activator, Hnf6

21 Jul 2012

Abstract excerpt

The Krüppel-like zinc finger transcription factor, Glis3, has been associated with neonatal diabetes in humans and mice, and implicated in the regulation of pancreatic β-cell generation. However, its precise function in the development of pancreatic β-cells has not yet been elucidated. In this study, we provide evidence that Glis3 regulates Neurogenin 3 (Ngn3) through its distal promoter region. Previous studies...

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PMID: 22820919
DOI: 10.1007/s10059-012-0109-z

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Glis3 Regulates Neurogenin 3 Expression in Pancreatic β-Cells and Interacts with Its Activator, Hnf6PMID 22820919Read ↗

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