Article
Low molecular weight protein tyrosine phosphatase genetic polymorphism and susceptibility to cancer development.
Cancer genetics and cytogenetics - 1 Feb 2008
Alho I, Clara Bicho M, Carvalho R, da Silva A P, Costa L, Bicho M
Abstract excerpt
Low molecular weight protein tyrosine phosphatases (LMW-PTPs) are a family of 18-kDa enzymes involved in cell growth regulation. Human acid phosphatase 1 (ACP1) is genetically polymorphic, and three common alleles segregating at the ACP1 locus on the short arm of chromosome 2 give rise to six phenotypes. Each allele appears to encode two electrophoretically different isozymes, fast and slow, which are produced in...
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