Article
Small amplicons high resolution melting analysis (SA-HRMA) allows successful genotyping of acid phosphatase 1 (ACP1) polymorphisms in the Italian population.
Clinica chimica acta; international journal of clinical chemistry - 1 Feb 2013
Minucci Angelo, Canu Giulia, Gentile Leonarda, Zuppi Cecilia, Giardina Bruno, Capoluongo Ettore
Abstract excerpt
BACKGROUND: The ACP1 gene, encoding a low-molecular-weight phosphotyrosine phosphatase (LMW-PTP), has been suggested as a common genetic factor of several human diseases, including inflammatory and autoimmune diseases, favism and tumors. For this reason, the ACP1 enzyme has been investigated by case-control studies for decades. Initially based on protein electrophoresis, the ACP1 phenotype is now determined by...
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