Article
Genotypes of cytosolic low-molecular-weight protein-tyrosine-phosphatase correlate with age at onset of type 1 diabetes in a sex-specific manner.
Metabolism: clinical and experimental - 1 Apr 2002
Bottini N, Meloni G F, Borgiani P, Giorgini A, Buzzetti R, Pozzilli P, Lucarelli P, Gloria-Bottini F
Abstract excerpt
We investigated the possible role of cytosolic low-molecular-weight protein-tyrosine-phosphatase (cLMWPTP or acid phosphatase locus 1 [ACP1]) in the mediation of age at onset of type 1 diabetes. ACP1 is an enzyme involved in signal transduction of T-cell receptors, insulin, and other growth factor receptors. We studied acid phosphatase polymorphism in 189 consecutive children with type 1 diabetes admitted to the...
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