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Article

Converting troponin C into calmodulin: effects of mutations in the central helix and of changes in temperature.

The international journal of biochemistry & cell biology - 1 Jun 2002

da Silva Elizabeth F, Oliveira Vanessa H, Sorenson Martha M, Barrabin Hector, Scofano Helena M

Abstract excerpt

Calmodulin (CaM) and troponin C (TnC) are the most similar members of EF-hand family and show few differences in the primary structure. Here, we use mutants of troponin that mimic calmodulin and changes in temperature to investigate the factors that determine their specificity as regulatory proteins. Using a double mutant of troponin that resembles calmodulin in lacking both the N-terminal helix and KGK(91-93) we...

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PMID: 11943596
DOI: 10.1016/s1357-2725(01)00170-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Converting troponin C into calmodulin: effects of mutations in the central helix and of changes in temperature.PMID 11943596Read ↗

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