Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Conformational changes in the parathyroid hormone receptor associated with activation by agonist.

Molecular endocrinology (Baltimore, Md.) - 1 May 2008

Thomas Beena E, Woznica Iwona, Mierke Dale F, Wittelsberger Angela, Rosenblatt Michael

Abstract excerpt

Binding of hormones to their cognate G protein-coupled receptors (GPCRs) induces conformational shifts within the receptor based on evidence from a few hormone-receptor systems. Employing an engineered disulfide bond formation strategy and guided by a previously established model of the PTH-PTH r...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Western
Share to Chlorocebus aethiops
Share to Computer Simulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to COS Cells

Share to Cysteine

Share to Factor Xa

Share to Parathyroid Hormone

Share to Receptor, Parathyroid Hormone, Type 1

Source

Open in PubMed Open full text

Identifiers

PMID: 18258686
DOI: 10.1210/me.2007-0520
PMCID: PMC2366190

Genes

PTH

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18258686-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Conformational changes in the parathyroid hormone receptor associated with activation by agonist.PMID 18258686Read ↗

Endogenous ligand recognition and structural transition of a human PTH receptorSemantic proximity Read ↗

Backbone Modification of a Parathyroid Hormone Receptor-1 Antagonist/Inverse Agonist.Semantic proximity Read ↗

Identification of determinants of inverse agonism in a constitutively active parathyroid hormone/parathyroid hormone-related peptide receptor by photoaffinity cross-linking and mutational analysis.Semantic proximity Read ↗

Rewiring PTH receptor signaling: Hormone dimerization restores endosomal signaling lost in hypocalcemia-linked PTH mutant.Semantic proximity Read ↗

Dimeric <sup>R25C</sup> PTH(1-34) Activates the Parathyroid Hormone-1 Receptor <i>in vitro</i> and Stimulates Bone Formation in Osteoporotic Female MiceSemantic proximity Read ↗

Mutation of Methionine to Asparagine but Not Leucine in Parathyroid Hormone Mimics the Loss of Biological Function upon Oxidation.Semantic proximity Read ↗

Pronounced conformational changes following agonist activation of the M(3) muscarinic acetylcholine receptor.Semantic proximity Read ↗

Ligand-specific changes in M3 muscarinic acetylcholine receptor structure detected by a disulfide scanning strategy.Semantic proximity Read ↗

Selective and nonselective inverse agonists for constitutively active type-1 parathyroid hormone receptors: evidence for altered receptor conformations.Semantic proximity Read ↗

Disulfide bonds determine growth hormone receptor folding, dimerisation and ligand binding.Semantic proximity Read ↗

The (1-14) fragment of parathyroid hormone (PTH) activates intact and amino-terminally truncated PTH-1 receptors.Semantic proximity Read ↗

Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.