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Article

Backbone Modification of a Parathyroid Hormone Receptor-1 Antagonist/Inverse Agonist.

ACS chemical biology - 21 Oct 2016

Cheloha Ross W, Watanabe Tomoyuki, Dean Thomas, Gellman Samuel H, Gardella Thomas J

Abstract excerpt

A backbone-modified peptide derived from parathyroid hormone (PTH) is shown to function as an inhibitor and inverse agonist of parathyroid hormone receptor-1 (PTHR1) signaling. This receptor acts to regulate calcium and phosphate homeostasis, as well as bone turnover and development. PTH is a natural agonist of PTHR1, and PTH(1-34) displays full activity relative to the natural 84-residue hormone. PTH(1-34) is...

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Source

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Identifiers

PMID: 27533344
DOI: 10.1021/acschembio.6b00404
PMCID: PMC5107307

Genes

PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Backbone Modification of a Parathyroid Hormone Receptor-1 Antagonist/Inverse Agonist.PMID 27533344Read ↗

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