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Mutation of Methionine to Asparagine but Not Leucine in Parathyroid Hormone Mimics the Loss of Biological Function upon Oxidation.

Biochemistry - 7 Jun 2022

Gaur Amit, Lipponen Jessica, Yang Yanmei, Armen Roger S, Wang Bin

Abstract excerpt

Human parathyroid hormone (PTH) is an 84-amino acid peptide that contains two methionine (Met) residues located at positions 8 and 18. It has long been recognized that Met residues in PTH are subject to oxidation to become Met sulfoxide, resulting in a decreased biological function of the peptide. However, the mechanism of the lost biological function of PTH oxidation remains elusive. To characterize whether the...

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PMID: 35533300
DOI: 10.1021/acs.biochem.2c00200
PMCID: PMC9179810

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