Article
The pathogenesis of classical Hodgkin's lymphoma: a model for B-cell plasticity.
Hematology/oncology clinics of North America - 1 Oct 2007
Mathas Stephan
Abstract excerpt
It has been shown that differentiated lymphoid cells can display a broad developmental potential and might even differentiate into other cell types. Recent data implicate such processes in the pathogenesis of classical Hodgkin's lymphoma (HL). In the malignant, B cell-derived Hodgkin's and Reed-Sternberg (HRS) cells of HL the expression of B cell-specific genes is lost, and B lineage-inappropriate genes are...
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