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Article

A mutant allele of MRE11 found in mismatch repair-deficient tumor cells suppresses the cellular response to DNA replication fork stress in a dominant negative manner.

Molecular biology of the cell - 1 Apr 2008

Wen Qin, Scorah Jennifer, Phear Geraldine, Rodgers Gary, Rodgers Sheila, Meuth Mark

Abstract excerpt

The interaction of ataxia-telangiectasia mutated (ATM) and the Mre11/Rad50/Nbs1 (MRN) complex is critical for the response of cells to DNA double-strand breaks; however, little is known of the role of these proteins in response to DNA replication stress. Here, we report a mutant allele of MRE11 found in a colon cancer cell line that sensitizes cells to agents causing replication fork stress. The mutant Mre11...

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Source

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Identifiers

PMID: 18256278
DOI: 10.1091/mbc.e07-09-0975
PMCID: PMC2291432

Genes

ATM
MRE11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A mutant allele of MRE11 found in mismatch repair-deficient tumor cells suppresses the cellular response to DNA replication fork stress in a dominant negative manner.PMID 18256278Read ↗

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