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Article

ABCG2/BCRP: Specific and Nonspecific Modulators

22 Dec 2016

Abstract excerpt

Multidrug resistance (MDR) in cancer cells is the development of resistance to a variety of structurally and functionally nonrelated anticancer drugs. This phenomenon has become a major obstacle to cancer chemotherapy seriously affecting the clinical outcome. MDR is associated with increased drug efflux from cells mediated by an energy-dependent mechanism involving the ATP-binding cassette (ABC) transporters,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28005280
DOI: 10.1002/med.21428

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