Article
Genome shuffling of Lactobacillus for improved acid tolerance.
Nature biotechnology - 1 Jul 2002
Patnaik Ranjan, Louie Susan, Gavrilovic Vesna, Perry Kim, Stemmer Willem P C, Ryan Chris M, del Cardayré Stephen
Abstract excerpt
Fermentation-based bioprocesses rely extensively on strain improvement for commercialization. Whole-cell biocatalysts are commonly limited by low tolerance of extreme process conditions such as temperature, pH, and solute concentration. Rational approaches to improving such complex phenotypes lack good models and are especially difficult to implement without genetic tools. Here we describe the use of genome...
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