Article
Strategies to improve the performance of rare variant association studies by optimizing the selection of controls.
Bioinformatics (Oxford, England) - 15 Nov 2015
Zhu Na, Heinrich Verena, Dickhaus Thorsten, Hecht Jochen, Robinson Peter N, Mundlos Stefan, Kamphans Tom, Krawitz Peter M
Abstract excerpt
MOTIVATION: When analyzing a case group of patients with ultra-rare disorders the ethnicities are often diverse and the data quality might vary. The population substructure in the case group as well as the heterogeneous data quality can cause substantial inflation of test statistics and result in spurious associations in case-control studies if not properly adjusted for. Existing techniques to correct for...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.