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Article

Utilization of Positive and Negative Controls to Examine Comorbid Associations in Observational Database Studies

27 Oct 2016

Abstract excerpt

BACKGROUND: Opportunities to leverage observational data for precision medicine research are hampered by underlying sources of bias and paucity of methods to handle resulting uncertainty. We outline an approach to account for bias in identifying comorbid associations between 2 rare genetic disorders and type 2 diabetes (T2D) by applying a positive and negative control disease paradigm. RESEARCH DESIGN:...

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PMID: 27787351
DOI: 10.1097/mlr.0000000000000640

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