Article
Trabecular bone deterioration in col9a1+/- mice associated with enlarged osteoclasts adhered to collagen IX-deficient bone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jun 2008
Wang Chiachien Jake, Iida Keisuke, Egusa Hiroshi, Hokugo Akishige, Jewett Anahid, Nishimura Ichiro
Abstract excerpt
INTRODUCTION: Short collagen IX, the exclusive isoform expressed by osteoblasts, is synthesized through alternative transcription of the col9a1 gene. The function of short collagen IX in bone was characterized in col9a1-null mutant mice. MATERIALS AND METHODS: Trabecular bone morphometry of lumbar bones and tibias was evaluated by muCT and nondecalcified histology. Osteoblastic and osteoclastic activities were...
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