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Article

Decreased Trabecular Bone Mass in Col22a1-Deficient Mice.

Cells - 4 Nov 2021

Zhao Wenbo, Wiedemann Philip, Wölfel Eva Maria, Neven Mona, Peters Stephanie, Imhof Thomas, Koch Manuel, Busse Björn, Amling Michael, Schinke Thorsten, Yorgan Timur Alexander

Abstract excerpt

The bone matrix is constantly remodeled by the coordinated activities of bone-forming osteoblasts and bone-resorbing osteoclasts. Whereas type I collagen is the most abundant bone matrix protein, there are several other proteins present, some of them specifically produced by osteoblasts. In a genome-wide expression screening for osteoblast differentiation markers we have previously identified two...

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PMID: 34831244
DOI: 10.3390/cells10113020
PMCID: PMC8616175

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