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Article

Nutritional Programming in the Rat Is Linked to Long-Lasting Changes in Nutrient Sensing and Energy Homeostasis in the Hypothalamus

21 Oct 2010

Abstract excerpt

BACKGROUND: Nutrient deficiency during perinatal development is associated with an increased risk to develop obesity, diabetes and hypertension in the adulthood. However, the molecular mechanisms underlying the developmental programming of the metabolic syndrome remain largely unknown. METHODOLOGY/PRINCIPAL FINDINGS: Given the essential role of the hypothalamus in the integration of nutritional, endocrine and...

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PMID: 20975839
DOI: 10.1371/journal.pone.0013537

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