Article
Completion of meiosis in male zebrafish (Danio rerio) despite lack of DNA mismatch repair gene mlh1.
Cell and tissue research - 1 Apr 2008
Leal Marcelo C, Feitsma Harma, Cuppen Edwin, França Luiz R, Schulz Rüdiger W
Abstract excerpt
Mlh1 is a member of DNA mismatch repair (MMR) machinery and is also essential for the stabilization of crossovers during the first meiotic division. Recently, we have shown that zebrafish mlh1 mutant males are completely infertile because of a block in metaphase I, whereas females are fertile but have aneuploid progeny. When studying fertility in males in a two-fold more inbred background, we have however...
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