Article
Mild defects in follicular development and reproductive performance in the heterozygous Hfm1 female mouse.
Reproduction (Cambridge, England) - 5 Feb 2026
Bhati Lavi, Ene Adriana C, Chen Jessy, Liang Manqi, Kazemi Parinaz, Martin Jacinta H, Slim Rima, Taketo Teruko
Abstract excerpt
Helicase for meiosis 1 (HFM1) is an ATP-dependent DNA helicase expressed primarily in the germ cells and plays a conserved role in meiotic synapsis and recombination. Biallelic HFM1 mutations are responsible for female infertility and various forms of pregnancy loss associated with primary ovarian insufficiency (POI), whereas monoallelic HFM1 mutations are found in women with milder forms of reproductive...
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