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Article

Inactivation of p14ARF as a key event for the progression of adult T cell leukemia/lymphoma.

Leukemia research - 1 Dec 2007

Kohno Tomoko, Yamada Yasuaki, Tawara Masayuki, Takasaki Yumi, Kamihira Shimeru, Tomonaga Masao, Matsuyama Toshifumi

Abstract excerpt

The INK4a/ARF locus encodes two different proteins, p16INK4a and p14ARF, which are crucial for two tumor suppressor pathways. We found that p14ARF mRNA expression was suppressed in 13 of 37 cases, among which 9 cases showed the inactivation of both of p14ARF and p16INK4a, and 4 cases showed the inactivation of p14ARF alone. The inactivation of p14ARF and the mutation of p53 are mutually exclusive. The patients...

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Identifiers

PMID: 18246599
DOI: 10.1016/j.leukres.2006.12.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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