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Article

Inactivation of p14ARF as a key event for the progression of adult T cell leukemia/lymphoma.

Leukemia research - 1 Dec 2007

Kohno Tomoko, Yamada Yasuaki, Tawara Masayuki, Takasaki Yumi, Kamihira Shimeru, Tomonaga Masao, Matsuyama Toshifumi

Abstract excerpt

The INK4a/ARF locus encodes two different proteins, p16INK4a and p14ARF, which are crucial for two tumor suppressor pathways. We found that p14ARF mRNA expression was suppressed in 13 of 37 cases, among which 9 cases showed the inactivation of both of p14ARF and p16INK4a, and 4 cases showed the i...

Topics

Acute Disease
Adult
Chronic Disease
Cyclin-Dependent Kinase Inhibitor p16
Disease Progression
Genes, p53
Humans
Leukemia-Lymphoma, Adult T-Cell
Mutation
Polymerase Chain Reaction
Prognosis
RNA, Messenger

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Survival Rate

Tumor Suppressor Protein p14ARF

Source

Identifiers

PMID: 18246599
DOI: 10.1016/j.leukres.2006.12.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-18246599-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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