Expression of LIF in transgenic mice results in altered thymic epithelium and apparent interconversion of thymic and lymph node morphologies.

doi:10.1002/j.1460-2075.1994.tb06391.x

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Article

Expression of LIF in transgenic mice results in altered thymic epithelium and apparent interconversion of thymic and lymph node morphologies.

The EMBO journal - 15 Mar 1994

Shen M M, Skoda R C, Cardiff R D, Campos-Torres J, Leder P, Ornitz D M

Abstract excerpt

Leukemia inhibitory factor (LIF) is a cytokine involved in embryonic and hematopoietic development. To investigate the effects of LIF on the lymphoid system, we generated a line of transgenic mice that expresses diffusible LIF protein specifically in T cells. These mice display two categories of phenotype that were not previously attributed to LIF overexpression. First, they display B cell hyperplasia, polyclonal...

Topics

Animals
Blood
Bone Marrow Cells
Bone Marrow Transplantation
CD4-CD8 Ratio
Epithelial Cells
Epithelium
Growth Inhibitors
Hypergammaglobulinemia
Interleukin-6
Leukemia Inhibitory Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymph Nodes

Lymphokines

Mice

Mice, Transgenic

Phenotype

T-Lymphocytes

Thymus Gland

Source

Open in PubMed Open full text

Identifiers

PMID: 8137821
DOI: 10.1002/j.1460-2075.1994.tb06391.x
PMCID: PMC394955

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8137821-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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