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Article

Expression of LIF in transgenic mice results in altered thymic epithelium and apparent interconversion of thymic and lymph node morphologies.

The EMBO journal - 15 Mar 1994

Shen M M, Skoda R C, Cardiff R D, Campos-Torres J, Leder P, Ornitz D M

Abstract excerpt

Leukemia inhibitory factor (LIF) is a cytokine involved in embryonic and hematopoietic development. To investigate the effects of LIF on the lymphoid system, we generated a line of transgenic mice that expresses diffusible LIF protein specifically in T cells. These mice display two categories of phenotype that were not previously attributed to LIF overexpression. First, they display B cell hyperplasia, polyclonal...

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Source

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Identifiers

PMID: 8137821
DOI: 10.1002/j.1460-2075.1994.tb06391.x
PMCID: PMC394955

Genes

LIF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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