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Article

Conservation of recombination hotspots in yeast.

Proceedings of the National Academy of Sciences of the United States of America - 27 Apr 2010

Tsai Isheng J, Burt Austin, Koufopanou Vassiliki

Abstract excerpt

Meiotic recombination does not occur randomly along a chromosome, but instead tends to be concentrated in small regions, known as "recombination hotspots." Recombination hotspots are thought to be short-lived in evolutionary time due to their self-destructive nature, as gene conversion favors recombination-suppressing alleles over recombination-promoting alleles during double-strand repair. Consistent with this...

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Identifiers

PMID: 20385822
DOI: 10.1073/pnas.0908774107
PMCID: PMC2867876

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