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Article

Live hot, die young: transmission distortion in recombination hotspots.

PLoS genetics - 9 Mar 2007

Coop Graham, Myers Simon R

Abstract excerpt

There is strong evidence that hotspots of meiotic recombination in humans are transient features of the genome. For example, hotspot locations are not shared between human and chimpanzee. Biased gene conversion in favor of alleles that locally disrupt hotspots is a possible explanation of the short lifespan of hotspots. We investigate the implications of such a bias on human hotspots and their evolution. Our...

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Share to Chromosome Segregation
Share to DNA Breaks, Double-Stranded
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetics, Population

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Source

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Identifiers

PMID: 17352536
DOI: 10.1371/journal.pgen.0030035
PMCID: PMC1817654

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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