Article
A 5' splice site enhances the recruitment of basal transcription initiation factors in vivo.
Molecular cell - 1 Feb 2008
Damgaard Christian Kroun, Kahns Søren, Lykke-Andersen Søren, Nielsen Anders Lade, Jensen Torben Heick, Kjems Jørgen
Abstract excerpt
Transcription and pre-mRNA splicing are interdependent events. Although mechanisms governing the effects of transcription on splicing are becoming increasingly clear, the means by which splicing affects transcription remain elusive. Using cell lines stably expressing HIV-1 or beta-globin mRNAs, harboring wild-type or various 5' splice site mutations, we demonstrate a strong positive correlation between splicing...
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