Article
Association between the macrophage inflammatory protein-l alpha gene polymorphism and Alzheimer's disease in the Chinese population.
Neuroscience letters - 12 Mar 2008
Li Keshen, Dai Dawei, Yao Lifen, Gu Xuefeng, Luan Kuan, Tian Wenjing, Zhao Yashuang, Wang Binyou
Abstract excerpt
Genetic polymorphisms in chemokine receptor and their natural ligand genes have been shown to modify the disease progression of Alzheimer's disease (AD). Human macrophage inflammatory protein-1 alpha (MIP-1alpha) is a chemotactic cytokine which plays a considerable role in AD pathogenesis, but its genetic contribution to AD has never been investigated. Recently, a biallelic dinucleotide microsatellite repeat (TA...
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