Acute leukemias in children with Down syndrome.

doi:10.1016/j.pcl.2007.11.001

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Article

Acute leukemias in children with Down syndrome.

Pediatric clinics of North America - 1 Feb 2008

Zwaan Michel C, Reinhardt Dirk, Hitzler Johann, Vyas Paresh

Abstract excerpt

Children with Down syndrome have an increased risk for developing both acute myeloid as well as lymphoblastic leukemia. These leukemias differ in presenting characteristics and underlying biology when compared with leukemias occurring in non-Down syndrome children. Myeloid leukemia in children with Down syndrome is preceded by a preleukemic clone (transient leukemia or transient myeloproliferative disorder),...

Topics

Antineoplastic Combined Chemotherapy Protocols
Child
Child, Preschool
Clinical Trials as Topic
Disease Progression
Down Syndrome
Humans
Infant
Infant, Newborn
Leukemia, Myeloid
Mutation
Precursor Cell Lymphoblastic Leukemia-Lymphoma

Source

Open in PubMed

Identifiers

PMID: 18242315
DOI: 10.1016/j.pcl.2007.11.001

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