Leukemia in Down syndrome: a review.

doi:10.3109/08880019209018329

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Article

Leukemia in Down syndrome: a review.

Pediatric hematology and oncology - 1 Jan 2000

Zipursky A, Poon A, Doyle J

Abstract excerpt

The incidence of leukemia is higher in children with Down syndrome (DS) than in normals. In approximately 50% of cases the type of leukemia is acute megakaryoblastic leukemia (AMKL) and it occurs during the first 4 years of life. The leukemic cell also has features of erythroid progenitors and therefore appears to be a precursor cell with biphenotypic properties. In addition, newborns with DS frequently develop...

Topics

Adolescent
Canada
Child
Child, Preschool
Down Syndrome
Genetic Predisposition to Disease
Hematopoietic Stem Cells
Humans
Hydrops Fetalis
Incidence
Infant
Infant, Newborn

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukemia, Megakaryoblastic, Acute

Megakaryocytes

Neoplastic Stem Cells

Nondisjunction, Genetic

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Preleukemia

Source

Open in PubMed

Identifiers

PMID: 1388043
DOI: 10.3109/08880019209018329

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1388043-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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