Article
Lung cancer risk associated with selenium status is modified in smoking individuals by Sep15 polymorphism.
European journal of nutrition - 1 Feb 2008
Jablonska Ewa, Gromadzinska Jolanta, Sobala Wojciech, Reszka Edyta, Wasowicz Wojciech
Abstract excerpt
BACKGROUND: Selenium (Se) is a trace element suggested to act chemopreventive in lung cancer. The mechanism by which Se suppresses tumour development may be associated with some of the functions of selenoproteins, including 15 kDa selenoprotein (Sep15). This protein exhibits antioxidant properties and thus may be involved in the process of carcinogenesis. Recently, it has been shown that the genetic polymorphism...
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