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Article

Growth inhibition and induction of apoptosis in mesothelioma cells by selenium and dependence on selenoprotein SEP15 genotype.

Oncogene - 24 Jun 2004

Apostolou Sinoula, Klein Julian O, Mitsuuchi Yasuhiro, Shetler Justin N, Poulikakos Poulikos I, Jhanwar Suresh C, Kruger Warren D, Testa Joseph R

Abstract excerpt

Malignant mesotheliomas (MMs) are aggressive tumors derived from mesothelial cells lining the lungs, pericardium and peritoneum, and are often associated with occupational asbestos exposure. Suppression subtractive hybridization was used to identify genes differentially expressed in MM cells compared to normal mesothelial cells. A gene, SEP15, encoding a 15-kDa selenium-containing protein was isolated using this...

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PMID: 15107826
DOI: 10.1038/sj.onc.1207683

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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