Article
Distribution and functional consequences of nucleotide polymorphisms in the 3'-untranslated region of the human Sep15 gene.
Cancer research - 1 Mar 2001
Hu Y J, Korotkov K V, Mehta R, Hatfield D L, Rotimi C N, Luke A, Prewitt T E, Cooper R S, Stock W, Vokes E E, Dolan M E, Gladyshev V N, Diamond A M
Abstract excerpt
Selenium has been shown to prevent cancer in a variety of animal model systems. Both epidemiological studies and supplementation trials have supported its efficacy in humans. However, the mechanism by which selenium suppresses tumor development remains unknown. Selenium is present in known human selenoproteins as the amino acid selenocysteine (Sec). Sec is inserted cotranslationally in response to UGA codons...
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