Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells.

Blood - 1 Apr 2008

Wu Ji, Meng Feng, Lu Henry, Kong Ling, Bornmann William, Peng Zhenghong, Talpaz Moshe, Donato Nicholas J

Abstract excerpt

Lyn kinase functions as a regulator of imatinib sensitivity in chronic myelogenous leukemia (CML) cells through an unknown mechanism. In patients who fail imatinib therapy but have no detectable BCR-ABL kinase mutation, we detected persistently activated Lyn kinase. In imatinib-resistant CML cells and patients, Lyn activation is BCR-ABL independent, it is complexed with the Gab2 and c-Cbl adapter/scaffold...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzamides
Share to Fusion Proteins, bcr-abl

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Imatinib Mesylate

Share to K562 Cells

Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Share to Multiprotein Complexes

Share to Proto-Oncogene Proteins c-cbl

Share to src-Family Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 18235045
DOI: 10.1182/blood-2007-08-109330
PMCID: PMC2275035

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells.PMID 18235045Read ↗

Association Between Imatinib-Resistant BCR-ABL Mutation-Negative Leukemia and Persistent Activation of LYN KinaseSemantic proximity Read ↗

CBL mutations drive PI3K/AKT signaling via increased interaction with LYN and PIK3R1.Semantic proximity Read ↗

CBL mutations promote activation of PI3K/AKT signaling via LYN kinaseSemantic proximity Read ↗

Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity.Semantic proximity Read ↗

A myristoyl/phosphotyrosine switch regulates c-Abl.Semantic proximity Read ↗

Lyn-mediated procaspase 8 dimerization blocks apoptotic signaling in B-cell chronic lymphocytic leukemiaSemantic proximity Read ↗

BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571Semantic proximity Read ↗

Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage.Semantic proximity Read ↗

Expression of LYN and PTEN genes in chronic myeloid leukemia and their importance in therapeutic strategy.Semantic proximity Read ↗

Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation.Semantic proximity Read ↗

β-Catenin is essential for survival of leukemic stem cells insensitive to kinase inhibition in mice with BCR-ABL-induced chronic myeloid leukemiaSemantic proximity Read ↗

Juvenile myelomonocytic leukaemia-associated mutation in Cbl promotes resistance to apoptosis via the Lyn-PI3K/AKT pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.