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Article

Juvenile myelomonocytic leukaemia-associated mutation in Cbl promotes resistance to apoptosis via the Lyn-PI3K/AKT pathway.

Oncogene - 5 Feb 2015

Bunda S, Qin K, Kommaraju K, Heir P, Ohh M

Abstract excerpt

Juvenile myelomonocytic leukaemia (JMML) is an aggressive myeloproliferative neoplasm in children characterized by granulocyte macrophage colony-stimulating factor (GM-CSF) hypersensitivity and resistance to chemotherapy. We recently identified c-Cbl (henceforth referred to as Cbl) as a GM-CSF receptor (GMR) responsive protein that targets Src for ubiquitin-mediated destruction upon GM-CSF stimulation and showed...

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Share to Antineoplastic Agents
Share to Apoptosis
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myelomonocytic, Juvenile

Share to Oncogene Protein v-akt

Share to Phosphatidylinositol 3-Kinases

Share to Proto-Oncogene Proteins c-cbl

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Source

Identifiers

PMID: 24469048
DOI: 10.1038/onc.2013.596

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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