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Article

The osterix transcription factor down-regulates interleukin-1 alpha expression in mouse osteosarcoma cells.

Molecular cancer research : MCR - 1 Jan 2008

Cao Ying, Jia Shu-Fang, Chakravarty Geetika, de Crombrugghe Benoit, Kleinerman Eugenie S

Abstract excerpt

K7M2 mouse osteosarcoma cells form lytic tumors and are deficient in osterix (Osx), a zinc finger-containing transcription factor required for osteoblast differentiation and bone formation. Our previous studies showed that replacement of Osx suppresses lytic bone destruction. Cytokines, including interleukin (IL)-1alpha, IL-6, IL-11, and prostaglandin E2, have been shown to stimulate osteoclast activity. We...

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Source

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Identifiers

PMID: 18234967
DOI: 10.1158/1541-7786.MCR-07-0090
PMCID: PMC2929177

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The osterix transcription factor down-regulates interleukin-1 alpha expression in mouse osteosarcoma cells.PMID 18234967Read ↗

Osterix, a Transcription Factor for Osteoblast Differentiation, Mediates Antitumor Activity in Murine OsteosarcomaSemantic proximity Read ↗

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