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Defective Human Immunodeficiency Virus-Specific CD8 <sup>+</sup> T-Cell Polyfunctionality, Proliferation, and Cytotoxicity Are Not Restored by Antiretroviral Therapy

3 Sept 2009

Abstract excerpt

Identifying the functions of human immunodeficiency virus (HIV)-specific CD8+ T cells that are not merely modulated by the level of virus but clearly distinguish patients with immune control from those without such control is of paramount importance. Features of the HIV-specific CD8+ T-cell response in antiretroviral-treated patients (designated Rx <50) and untreated patients (long-term nonprogressors [LTNP])...

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PMID: 19726501
DOI: 10.1128/jvi.01153-09

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