Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells

7 Feb 2006

Abstract excerpt

Establishing a CD8(+) T cell-mediated immune correlate of protection in HIV disease is crucial to the development of vaccines designed to generate cell-mediated immunity. Historically, neither the quantity nor breadth of the HIV-specific CD8(+) T-cell response has correlated conclusively with protection. Here, we assess the quality of the HIV-specific CD8(+) T-cell response by measuring 5 CD8(+) T-cell functions...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV/AIDS Research and Interventions
Share to HIV Research and Treatment
Share to Immune Cell Function and Interaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16467198
DOI: 10.1182/blood-2005-12-4818

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cellsPMID 16467198Read ↗

Characterization of virus-specific CD8(+) effector T cells in the course of HIV-1 infection: longitudinal analyses in slow and rapid progressors.Semantic proximity Read ↗

Relative contribution of HIV-specific functional lymphocyte subsets restricted by protective and non-protective HLA alleles.Semantic proximity Read ↗

HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors.Semantic proximity Read ↗

Abundance of Early Functional HIV-Specific CD8+ T Cells Does Not Predict AIDS-Free Survival TimeSemantic proximity Read ↗

Comparisons of CD8<sup>+</sup>T Cells Specific for Human Immunodeficiency Virus, Hepatitis C Virus, and Cytomegalovirus Reveal Differences in Frequency, Immunodominance, Phenotype, and Interleukin-2 ResponsivenessSemantic proximity Read ↗

Frequency and function of HIV-specific CD8(+) T cells.Semantic proximity Read ↗

Early and prolonged antiretroviral therapy is associated with an HIV-1-specific T-cell profile comparable to that of long-term non-progressors.Semantic proximity Read ↗

Plasmatic Levels of IL-18, IP-10, and Activated CD8+ T Cells Are Potential Biomarkers to Identify HIV-1 Elite Controllers With a True Functional Cure ProfileSemantic proximity Read ↗

Comprehensive phenotyping of circulating immune cell subsets in people living with HIVSemantic proximity Read ↗

Early Gag Immunodominance of the HIV-Specific T-Cell Response during Acute/Early Infection Is Associated with Higher CD8 <sup>+</sup> T-Cell Antiviral Activity and Correlates with Preservation of the CD4 <sup>+</sup> T-Cell CompartmentSemantic proximity Read ↗

Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control.Semantic proximity Read ↗

Mechanisms of HIV non-progression; robust and sustained CD4+ T-cell proliferative responses to p24 antigen correlate with control of viraemia and lack of disease progression after long-term transfusion-acquired HIV-1 infectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.