Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Long-term immune reconstitution in RAG-1-deficient mice treated by retroviral gene therapy: a balance between efficiency and toxicity

21 Sept 2005

Abstract excerpt

Severe combined immunodeficiency (SCID) caused by mutations in RAG1 or RAG2 genes is characterized by a complete block in T- and B-cell development. The only curative treatment is allogeneic hematopoietic stem cell transplantation, which gives a high survival rate (90%) when an HLA-genoidentical donor exists but unsatisfactory results when only partially compatible donors are available. We have thus been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Viral Infections and Immunology Research
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16174758
DOI: 10.1182/blood-2005-05-2032

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Long-term immune reconstitution in RAG-1-deficient mice treated by retroviral gene therapy: a balance between efficiency and toxicityPMID 16174758Read ↗

Gene therapy of RAG-2−/− mice: sustained correction of the immunodeficiencySemantic proximity Read ↗

Partial correction of immunodeficiency by lentiviral vector gene therapy in mouse models carrying Rag1 hypomorphic mutations.Semantic proximity Read ↗

Recombination-activating gene 1 (Rag1)-deficient mice with severe combined immunodeficiency treated with lentiviral gene therapy demonstrate autoimmune Omenn-like syndrome.Semantic proximity Read ↗

Successful Preclinical Development of Gene Therapy for Recombinase-Activating Gene-1-Deficient SCIDSemantic proximity Read ↗

Gene Therapy for X-Linked Severe Combined Immunodeficiency: Where Do We Stand?Semantic proximity Read ↗

Immune Reconstitution After Gene Therapy Approaches in Patients With X-Linked Severe Combined Immunodeficiency DiseaseSemantic proximity Read ↗

Innovative Cell-Based Therapies and Conditioning to Cure RAG Deficiency.Semantic proximity Read ↗

Complete correction of murine Artemis immunodeficiency by lentiviral vector-mediated gene transferSemantic proximity Read ↗

Restoration of Human B-cell Differentiation Into NOD-SCID Mice Engrafted With Gene-corrected CD34+ Cells Isolated From Artemis or RAG1-deficient PatientsSemantic proximity Read ↗

Human Lentiviral Gene Therapy Restores the Cellular Phenotype of Autosomal Recessive Complete IFN-γR1 DeficiencySemantic proximity Read ↗

Severe combined immunodeficiency. A model disease for molecular immunology and therapySemantic proximity Read ↗

Early death and severe lymphopenia caused by ubiquitous expression of the Rag1 and Rag2 genes in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.