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Immunohistochemical and Biochemical Studies Demonstrate a Distinct Profile of α-Synuclein Permutations in Multiple System Atrophy

1 Sept 2000

Abstract excerpt

Although alpha-synuclein (alpha-syn) has been implicated as a major component of the abnormal filaments that form glial cytoplasmic inclusions (GCIs) in multiple system atrophy (MSA), it is uncertain if GCIs are homogenous and contain full-length alpha-syn. Since this has implications for hypotheses about the pathogenesis of GCIs, we used a novel panel of antibodies to defined regions throughout alpha-syn in...

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PMID: 11005264
DOI: 10.1093/jnen/59.9.830

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