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Article

Transcriptional activation of the human claudin-18 gene promoter through two AP-1 motifs in PMA-stimulated MKN45 gastric cancer cells.

American journal of physiology. Gastrointestinal and liver physiology - 1 Jan 2008

Yano Koichi, Imaeda Takashi, Niimi Tomoaki

Abstract excerpt

Claudin-18 (CLDN18), a member of the claudin family of proteins that are structural components of tight junctions, has two alternatively spliced variants, claudin-18a1 and claudin-18a2, which are highly expressed in lung and stomach, respectively. Downregulation of claudin-18a2 is associated with gastric cancers of an intestinal phenotype; however, the mechanisms regulating its expression have not been defined....

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Source

Identifiers

PMID: 18032479
DOI: 10.1152/ajpgi.00328.2007

Genes

CLDN18

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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