Article
Hsc70 focus formation at the periphery of HSV-1 transcription sites requires ICP27.
PloS one - 30 Jan 2008
Li Ling, Johnson Lisa A, Dai-Ju Jenny Q, Sandri-Goldin Rozanne M
Abstract excerpt
BACKGROUND: The cellular chaperone protein Hsc70, along with components of the 26S proteasome and ubiquitin-conjugated proteins have been shown to be sequestered in discrete foci in the nuclei of herpes simplex virus 1 (HSV-1) infected cells. We recently reported that cellular RNA polymerase II (RNAP II) undergoes proteasomal degradation during robust HSV-1 transcription, and that the immediate early protein...
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