Article
[Current availability of genetic information of drug metabolizing enzymes, particularly on cytochrome P450(CYP)].
Nihon rinsho. Japanese journal of clinical medicine - 1 Aug 2001
Yamazoe Y, Nagata K
Abstract excerpt
Genetic polymorphisms of drug metabolizing enzymes often associated with clinical alteration among individuals. Current understanding of the molecular basis of the polymorphism of drug metabolizing enzymes is reviewed, particularly on cytochrome P450(CYP). Pharmacogenetic/pharmacogenomic studies are started for the estimation of pharmacokinetics of drugs, but now expanding for a tool of individual optimization of...
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