Article
Maximizing association statistics over genetic models.
Genetic epidemiology - 1 Apr 2008
González Juan R, Carrasco Josep L, Dudbridge Frank, Armengol Lluís, Estivill Xavier, Moreno Victor
Abstract excerpt
The assessment of the association between a candidate locus and a disease may require the assumption of an inheritance model. Most researchers select the additive model and test the association with the Cochran-Armitage trend test. This test assumes a dose-response effect with regard to the number of copies of the variant allele. However, if there is reason to expect dominance or recessiveness in the effect of...
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