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Article

Preferential loss of mismatch repair function in refractory and relapsed acute myeloid leukemia: potential contribution to AML progression.

Cell research - 1 Feb 2008

Mao Guogen, Yuan Fenghua, Absher Kimberly, Jennings C Darrell, Howard Dianna S, Jordan Craig T, Gu Liya

Abstract excerpt

Acute myeloid leukemia (AML) is an aggressive hematological cancer. Despite therapeutic regimens that lead to complete remission, the vast majority of patients undergo relapse. The molecular mechanisms underlying AML development and relapse remain incompletely defined. To explore whether loss of DNA mismatch repair (MMR) function is involved in AML, we screened two key MMR genes, MSH2 and MLH1, for mutations and...

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Topics

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Share to Adaptor Proteins, Signal Transducing
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mismatch Repair

Share to Leukemia, Myeloid, Acute

Share to MutL Protein Homolog 1

Share to MutS Homolog 2 Protein

Share to Neoplasm Proteins

Share to Recurrence

Source

Identifiers

PMID: 18227862
DOI: 10.1038/cr.2008.14

Genes

MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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