Article
MSH6 haploinsufficiency at relapse contributes to the development of thiopurine resistance in pediatric B-lymphoblastic leukemia.
Haematologica - 1 May 2018
Evensen Nikki A, Madhusoodhan P Pallavi, Meyer Julia, Saliba Jason, Chowdhury Ashfiyah, Araten David J, Nersting Jacob, Bhatla Teena, Vincent Tiffaney L, Teachey David, Hunger Stephen P, Yang Jun, Schmiegelow Kjeld, Carroll William L
Abstract excerpt
Survival of children with relapsed acute lymphoblastic leukemia is poor, and understanding mechanisms underlying resistance is essential to developing new therapy. Relapse-specific heterozygous deletions in MSH6, a crucial part of DNA mismatch repair, are frequently detected. Our aim was to determine whether MSH6 deletion results in a hypermutator phenotype associated with generation of secondary mutations...
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