Article
Drug treatment in the development of mismatch repair defective acute leukemia and myelodysplastic syndrome.
DNA repair - 13 May 2003
Casorelli Ida, Offman Judith, Mele Luca, Pagano Livio, Sica Simona, D'Errico Mariarosaria, Giannini Giuseppe, Leone Giuseppe, Bignami Margherita, Karran Peter
Abstract excerpt
DNA from therapy-related acute leukemia/myelodysplastic syndrome cases (tAL/MDS) from the GIMEMA [Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto] Archive was examined for the microsatellite instability (MSI(+)) phenotype that is diagnostic for defective DNA mismatch repair. More than 60% (16/25) of tAL/MDS cases were MSI(+) in contrast to <4% (0/28) of de novo cases. hMLH1 gene silencing was rare and...
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